Borderline personality disorder (BPD) is a severe psychiatric disorder characterized by a pervasive instability in affects, impulse, sense of self, and interpersonal relationships. The guidelines for the treatment of BPD highlight the role of disorder-specific psychotherapies. Interpersonal psychotherapy was adapted for BPD by Markowitz (IPT-BPD). The efficacy of this treatment was studied at the University of Turin in patients who received a combination of IPT-BPD with an antidepressant. Results showed that combined treatment was superior to antidepressant alone on BPD core symptoms (disturbed interpersonal relationships, affective instability, and impulsive dyscontrol). It was also more effective on anxiety and on subjective quality of life [2010]. The increased effects of combined therapy were mostly maintained during 2 years of follow-up [2016]. Bellino and Bozzatello proposed an ameloriated version of IPT-BPD (IPT-BPD-R) with a prolonged duration of treatment, a stronger support of patients during crises, a maintenance phase, and interpersonal counseling for family members [2015]. The efficacy of IPT-BPD-R as single treatment was tested by a controlled study. Results indicated a significant decrease of general psychopatology, specific BPD symptoms, and social functioning in comparison with control patients in waiting list [2020]. In addition, the clinical and functional effects of IPT-BPD-R were found related to functional changes of brain areas (temporal parietal junction and anterior cingulate cortex) observed at fMRI with a task of autobiographical memory (self referential processing and mentalization) [2021]. A clinical trial is currently underway to evaluate an intervention of interpersonal group therapy for BPD. In particular, the effects of the association of group therapy with individual IPT are compared with individual IPT alone and initial results are promising in terms of improvement of BPD symptoms, social functioning, interpersonal problems, and mentalization. Findings will be discussed considering opportunities to improve and tailor clinical management of BPD patients.